Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide
نویسندگان
چکیده
منابع مشابه
Chemoprevention strategies in lung carcinogenesis.
Chemoprevention entails using specific agents to suppress carcinogenesis and thereby prevent the development of primary or second primary cancers. Because the concept of chemoprevention in patients with or at risk of lung cancer is new, ongoing clinical trials are based on data from epidemiologic and preclinical research, as well as on results of chemoprevention studies in head and neck cancer....
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This investigation is part of a continuing effort to develop effective chemoprevention for carcinogenesis of the lung. The present study explores the use of aerosol administrations for this purpose. The agent selected for initial study was the synthetic glucocorticoid budesonide. This selection was based on previous work in which budesonide added to the diet was found to inhibit pulmonary adeno...
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This investigation is part of a continuing effort to develop effective chemoprevention for carcinogenesis of the lung. The present study ex plores the use of aerosol administrations for this purpose. The agent selected for initial study was the synthetic glucocorticoid budesonide. This selection was based on previous work in which budesonide added to the diet was found to inhibit pulmonary aden...
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Chemoprevention is a clinical strategy to block or reverse carcinogenesis before the development of invasive cancer. Studies of chemoprevention in the lungs and upper aerodigestive tract have relied on the field carcinogenesis hypothesis, which predicts that diffuse epithelial injury will result from exposure of that epithelium to carcinogens. This hypothesis is supported by the frequent occurr...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2019
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-17-0402